ea0059p172 | Obesity & metabolism | SFEBES2018
Kirstein Anna
, Penke Melanie
, Kiess Wieland
, Garten Antje
Background/aim: Patients with germline mutations in the tumor suppressor PTEN frequently develop single or multiple lipomas. PTEN antagonizes the phosphatidylinositide3-kinase/AKT/mechanistic target of rapamycin (PI3K/AKT/mTOR) pathway, which promotes cell proliferation and is involved in adipocyte differentiation. The aim of this study was to investigate the mechanisms leading to aberrant adipose tissue growth using PTEN knock-down cell models....